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Hand-transmitted vibration is one of the most common physical harmful factors in the workplace，and the hand-arm vibration syndrome caused by it lacks effective treatment, and seriously affects the physical and mental health of the involved workers. As an important target for hand-transmitted vibration, the nervous system has attracted increasing attention from scholars, and much progress has been made in recent years in studying the effects of hand-transmitted vibration on nervous system function. Based on related literature at home and abroad, this paper introduced the hand-transmitted vibration-associated damage in peripheral, autonomic, and central nervous systems, and then explored the associated influence factors, like vibration frequency, environment temperature, and individual factors. The potential directions for further research were also proposed.
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Background Hand-transmitted vibration is one of the most common occupational hazards and is closely related to symptoms of fingertip terminal nerve damage. Objective To analyze the effects of hand-transmitted vibration on the terminal nerve of fingertips. Methods We systematically searched literature about the effects of hand-transmitted vibration on fingertip terminal nerve at home and abroad. The outcome index was the number (rate) of fingertip terminal nerve symptoms reported by the vibration group and the control group, such as finger numbness and finger tingling, and the search period was from database inception to December 2021. The quality of cross-sectional studies was assessed using the criteria recommended by the Agency for Healthcare Research and Quality (AHRQ), and the quality of cohort studies was assessed by the Newcastle-Ottawa Scale (NOS). NoteExpress 3.2 was used for literature management, and Excel 2003 was used for data collection and extraction. RevMan 5.4.1 software was used for statistical analysis, and random effect model was used to calculate the OR value of pooled effects and to draw forest plots. Subgroup analysis was carried out according to the working years with vibration exposure. At the same time, sensitivity analysis was performed after excluding studies with the largest weight and funnel plots were generated to evaluate publication bias. Results A total of 3619 articles were retrieved, and 39 articles were finally included, including 29 Chinese articles and 10 English articles; 36 cross-sectional studies and 3 cohort studies. In total, 8399 subjects were studied, including 5673 cases in the vibration exposure group and 2726 cases in the control group. Random effect model was used to merge the included literature. The results of meta-analysis showed that compared with the control group, hand-transmitted vibration was significantly associated with the self-reported occurrence of finger numbness (OR=8.29, 95%CI: 5.43-12.66), finger tingling (OR=7.50, 95%CI: 4.78-11.77), finger swelling (OR=8.25, 95%CI: 4.06-16.76), finger stiffness (OR=10.71, 95%CI: 3.60-31.87), finger trembling (OR=5.11, 95%CI: 2.60-10.04), hand weakness (OR=11.05, 95%CI: 3.98-30.68), hand sweating (OR=2.70, 95%CI: 1.64-4.43), hand coldness (OR=3.54, 95%CI: 2.42-5.18) (P<0.01). The subgroup analysis showed that the odds ratios of both finger numbness and finger tingling increased in the early and middle stages of vibration exposure (<5 years and 5-10 years of exposure duration）(finger numbness: OR=11.11, 19.07; finger tingling: OR=4.70, 16.55, respectively)(P<0.01), and decreased in the late stage of vibration exposure (10-15 years and ≥15 years of exposure duration) (finger numbness: OR=9.57, 2.30; finger tingling: OR=5.71, 6.00, respectively) (P<0.01). The results of sensitivity analysis showed a stable pooled effect (OR=13.96, 95%CI: 4.85-40.13, Z=4.89, P<0.01). The funnel plot results showed positive publication bias. Conclusion Occupational exposure to hand-transmitted vibration can cause finger numbness, finger tingling, finger swelling, finger stiffness, finger trembling, hand weakness, hand sweating, and hand coldness.
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The hand-arm vibration disease due to widespread hand-transmitted vibration operations is difficult to cure and seriously affects the health and quality of life of patients. Focusing on the prevention and control of hand-transmitted vibration and its occupational hazards, advances in occupational health relevant to hand-transmitted vibration were reviewed from the aspects of occupational hazard status, health impact, exposure monitoring, prevention and control of hand-transmitted vibration, as well as health surveillance, diagnosis, and treatment of hand-arm vibration disease. In addition, further suggestions on prevention and control of occupational hazards related with hand-transmitted vibration were prospected.
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@#AIM: To investigate the changes of serum cytokines in patients with polypoid chorioretinopathy and analyze its risk factors. <p>METHODS: Select 50 cases of PCV patients in our hospital from December 2018 to May 2019 served as observation group, 50 cases of senile cataract patients who want to undergo cataract surgery served as control group. The levels of inflammatory factors and angiogenic factors were compared between the two groups, and the general clinical data were analyzed by single factor and logistic regression. <p>RESULTS: The levels of IL-8, MCP-1, VEGF and PEDF in the observation group were significantly higher than those in the control group(<i>P</i><0.01). The results of ANOVA showed that there was significant difference between smoking history and hypertension between the two groups(<i>P</i><0.05); Logistic regression analysis showed that the increased levels of IL-8, MCP-1, VEGF, PEDF, smoking history and hypertension were independent risk factors for PCV. <p>CONCLUSION: The serum levels of IL-8, MCP-1, VEGF and PEDF in PCV patients were all increased abnormally, which was closely related to smoking history and hypertension.
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Neoadjuvant therapy combined with surgery is a very promising clinical treatment strategy for esophageal cancer. Combined with its effectiveness and safety, neoadjuvant radiotherapy can be used as a treatment method for severe esophageal cancer and unresectable esophageal cancer. Neoadjuvant chemotherapy has a higher value in the treatment of adenocarcinoma. Neoadjuvant cheoradiotherapy can be used as the recommended treatment scheme for patients with squamous cancer.
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@#AIM:To explore the effects of Conbercept combined with laser on inflammatory factors, oxidative stress levels and retinal hemodynamics in diabetic retinopathy. <p>METHODS: One hundred patients with diabetic retinopathy who were diagnosed and treated in our hospital from October 2015 to February 2017 were randomly divided into control group and observation group, 50 cases in each group. The control group was given laser treatment. The observation group was treated with conbercept on the basis of the control group. Afterwards, the clinical efficacy, inflammatory factors, oxidative stress and retinal hemodynamic level were tested before and after treatment of two groups of patients. <p>RESULTS: There was no significant difference in LogMAR value and retinal thickness between the two groups before treatment(<i>P</i>>0.05). After treatment, both LogMAR values of visual acuity and retinal thickness decreased significantly in the two groups. After treatment, the LogMAR value of visual acuity of the observation group was 0.65±0.05, the thickness of retina was 157.97±15.51μm, which was significantly lower than that of the control group(<i>P</i><0.05). After treatment, the levels of IL-1β, IL-6 and IL-8 in serum were significantly lower than those before treatment. The levels of IL-1β, IL-6 and IL-8 of the observation group were 16.93±0.48ng/L, 92.22±1.03pg/mL and 0.33±0.06ng/L respectively, which were significantly lower than those of the control group after treatment(<i>P</i><0.05). The levels of MDA, LHP and ROS in the two groups significantly decreased after treatment, and the levels of MDA, LHP and ROS in the observation group were 4.16±0.21μmol/L, 164.97±6.51μmol/L and 261.15±14.44μmol/L, which was significantly lower than that of the control group after treatment(<i>P</i><0.05). After treatment, PSV and EDV levels in both groups significantly increased, and RI levels significantly decreased. The levels of PSV and EDV in the observation group were 9.59±0.22cm/s and 2.96±0.05cm/s, respectively, which were significantly higher than those in the control group. The RI level in the control group was 0.66±0.04, which was significantly lower than that in the control group(<i>P</i><0.05). <p>CONCLUSION: Conbercept combined with laser can effectively improve the vision of patients with retinopathy, reduce retinal thickness, reduce the levels of inflammatory cytokines and oxidative stress, and improve retinal hemodynamics. The curative effect is reliable.
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<p><b>OBJECTIVE</b>To analyze the differential proteomics in human umbilical cord mesenchymal stem cells (MSC) induced by chemical hypoxia-mimetic agent cobalt chloride (CoCl(2)) by two-dimensional gel electrophoresis (2-DE) and mass-spectrometry.</p><p><b>METHODS</b>2-DE was performed to separate proteins from treated and untreated human umbilical cord MSC with CoCl(2). 2-DE images were analyzed by ImageMaster 2D Platinum software 6.0. The differential expressed proteins was identified by MALDI-TOF-MS. The differential proteins were classified based on their functions.</p><p><b>RESULTS</b>2-DE reference patterns of CoCl(2) treated human umbilical cord MSC were established. A total of twenty-six differential proteins were identified, of them eleven proteins were up-regulated and fifteen down-regulated. Their biological functions involved in carbohydrate metabolism, protein metabolism and modification, lipid metabolism, coenzyme and prosthetic group metabolism, cell cycle, immunity and defense, cell structure and motility, signal transduction, protein targeting and localization, neuronal activities, muscle contraction, etc. Peroxiredoxin1 (Prdx) was down-regulated, whereas alpha-enolase (ENO1) and vesicle amine transport protein 1 homolog (VAT1) up-regulated.</p><p><b>CONCLUSION</b>The effects of hypoxia on human umbilical cord MSC were participated by multiple proteins and involved in multiple functional pathways.</p>